Late gestation over- and undernutrition predispose for visceral adiposity in response to a post-natal obesogenic diet, but with differential impacts on glucose-insulin adaptations during fasting in lambs Khanal,
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چکیده
Citation for published version (APA): Khanal, P., Husted, S. V., Axel, A. M. D., Johnsen, L., Pedersen, K. L., Mortensen, M. S., ... Nielsen, M. O. (2014). Late gestation overand undernutrition predispose for visceral adiposity in response to a post-natal obesogenic diet, but with differential impacts on glucose-insulin adaptations during fasting in lambs. Acta Physiologica (Print), 210(1), 110-126. DOI: 10.1111/apha.12129
منابع مشابه
Late gestation over- and undernutrition predispose for visceral adiposity in response to a post-natal obesogenic diet, but with differential impacts on glucose-insulin adaptations during fasting in lambs.
AIM To investigate if late gestation under- or overnutrition has similar adverse impacts on visceral adiposity, metabolic and endocrine function in sheep, and if subsequent exposure to a high-fat diet in early post-natal life exaggerates the prenatal programming outcomes later in life. METHODS Thirty-six twin-pregnant ewes were fed a NORM (fulfilling 100% of daily requirements for energy and ...
متن کاملProgramming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model.
AIM Exposure to adverse intra-uterine conditions can predispose for metabolic disorders later in life. By using a sheep model, we studied (i) how programming of glucose-insulin homoeostasis during late gestation is manifested later in life depending on the early post-natal dietary exposure and (ii) whether dietary alteration in obese individuals can prevent adverse outcomes of early life progra...
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In this study, the effects of late gestational undernutrition (LGU) on plasma concentration of insulin-like growth factor 1 (IGF-I), leptin, insulin and glucose in subsequent sucking lambs was investigated. Ten twin-bearing ewes were fed either restrictedly (Restricted) or adequately (Control) during the last six weeks of gestation and were fed ad libitum after parturition. Blood samples were t...
متن کاملLate gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life.
We have developed a sheep model to facilitate studies of the fetal programming effects of mismatched perinatal and postnatal nutrition. During the last trimester of gestation, twenty-one twin-bearing ewes were fed a normal diet fulfilling norms for energy and protein (NORM) or 50% of a normal diet (LOW). From day 3 postpartum to 6 months (around puberty) of age, one twin lamb was fed a conventi...
متن کاملLong-Term Impacts of Foetal Malnutrition Followed by Early Postnatal Obesity on Fat Distribution Pattern and Metabolic Adaptability in Adult Sheep
We aimed to investigate whether over- versus undernutrition in late foetal life combined with obesity development in early postnatal life have differential implications for fat distribution and metabolic adaptability in adulthood. Twin-pregnant ewes were fed NORM (100% of daily energy and protein requirements), LOW (50% of NORM) or HIGH (150%/110% of energy/protein requirements) diets during th...
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تاریخ انتشار 2017